The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage.

Shengpan ChenYuchun ZuoLei HuangPrativa SherchanJian ZhangZhengtao YuJianhua PengJunyi ZhangLianhua ZhaoDesislava DoychevaFei LiuJohn H ZhangYing XiaJi-Ping Tang

Published in: British journal of pharmacology (2019)

RO27-3225 suppressed NLRP1-dependent neuronal pyroptosis and improved neurological function, possibly mediated by activation of MC4 receptor and inhibition of ASK1/JNK/p38 MAPK signalling pathways, after experimental ICH in mice. The MC4 receptor may be a promising therapeutic target for the management of ICH.

Keyphrases

nlrp inflammasome
mouse model
signaling pathway
cell death
cerebral ischemia
induced apoptosis
binding protein
type diabetes
metabolic syndrome
insulin resistance
skeletal muscle
brain injury