An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.
Fareesa AftabAlice Rodriguez-FuguetLuis SilvaIkei S KobayashiJiao SunKaterina PolitiElena LevantiniWei ZhangSusumu S KobayashiWen Cai ZhangPublished in: British journal of cancer (2023)
AICAR represses the MUC1 activity in EGFR-mutant lung cancer, disrupting protein-protein interactions between MUC1-CT and JAK1 and EGFR.