The emerging roles of histone demethylases in cancers.
Dali TongYing TangPeng ZhongPublished in: Cancer metastasis reviews (2024)
Modulation of histone methylation status is regarded as an important mechanism of epigenetic regulation and has substantial clinical potential for the therapy of diseases, including cancer and other disorders. The present study aimed to provide a comprehensive introduction to the enzymology of histone demethylases, as well as their cancerous roles, molecular mechanisms, therapeutic possibilities, and challenges for targeting them, in order to advance drug design for clinical therapy and highlight new insight into the mechanisms of these enzymes in cancer. A series of clinical trials have been performed to explore potential roles of histone demethylases in several cancer types. Numerous targeted inhibitors associated with immunotherapy, chemotherapy, radiotherapy, and targeted therapy have been used to exert anticancer functions. Future studies should evaluate the dynamic transformation of histone demethylases leading to carcinogenesis and explore individual therapy.
Keyphrases
- dna methylation
- papillary thyroid
- clinical trial
- squamous cell
- cancer therapy
- lymph node metastasis
- squamous cell carcinoma
- emergency department
- genome wide
- childhood cancer
- risk assessment
- drug delivery
- radiation induced
- bone marrow
- study protocol
- cell therapy
- phase ii
- replacement therapy
- phase iii
- chemotherapy induced