Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.

Kang MiaoTing PanYong MouLei ZhangWeining XiongYongjian XuJun YuYi Wang

Published in: Therapeutic advances in chronic disease (2020)

In general, scutellarein might exert therapeutic effects on pulmonary fibrosis by altering the differentiation, proliferation, and apoptosis of fibroblasts. Although scutellarein has been demonstrated to be safe in mice, further studies are required to investigate the efficacy of scutellarein in patients with IPF.

Keyphrases

pulmonary fibrosis
endoplasmic reticulum stress
oxidative stress
cell cycle arrest
signaling pathway
cell death
idiopathic pulmonary fibrosis
pi k akt
high fat diet induced
type diabetes
extracellular matrix
metabolic syndrome
skeletal muscle
cell proliferation
adipose tissue
case control