Prazosin during fear conditioning facilitates subsequent extinction in male C57Bl/6N mice.
Elizabeth K LucasWan-Chen WuCiorana Roman-OrtizRoger L ClemPublished in: Psychopharmacology (2018)
Our results indicate that α1-AR activity during aversive conditioning is dispensable for memory acquisition but renders conditioned fear more impervious to extinction. This suggests that behavioral flexibility is constrained by noradrenaline at the time of initial learning via activation of a specific AR isoform.