Discovery of a novel and selective fungicide that targets fungal cell wall to treat dermatomycoses: 1,3-bis(3,4-dichlorophenoxy)propan-2-aminium chloride.

Daiane F Dalla LanaStefânia Neiva LavoratoLaura Minussi GiulianiLetícia CruzWilliam LopesMarilene Henning VainsteinIgor Camargo FontanaAline Rigon ZimmerMurillo de Araújo FreitasSaulo Fernandes de AndradeRicardo José AlvesAlexandre Meneghello Fuentefria

Published in: Mycoses (2019)

Therefore, the compound 2j demonstrated the potential for antifungal drug development, with a action mechanism elucidated and already applied in a semisolid formulation as a new therapeutic option for fungal skin infections.

Keyphrases

cell wall
small molecule
candida albicans
drug delivery
ionic liquid
high throughput
soft tissue
wound healing
climate change