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Immune-Desert Tumor Microenvironment in Thoracic SMARCA4-Deficient Undifferentiated Tumors with Limited Efficacy of Immune Checkpoint Inhibitors.

Justine GantzerGuillaume DavidsonBujamin VokshiNoëlle WeingertnerAntoine BougoüinMarco MoreiraVéronique LindnerGuillaume LacroixCéline MascauxMarie-Pierre ChenardFrançois BertucciIrwin DavidsonJean-Emmanuel KurtzCatherine Sautès-FridmanWolf H FridmanGabriel G Malouf
Published in: The oncologist (2022)
SMARCA4-UT mainly have an immune desert TME with limited efficacy to ICI. TME of SMARCA4-driven tumors varies according to the cell of origin questioning the interplay between BAF alterations, cell ontogeny and immunity.
Keyphrases
  • single cell
  • cell therapy
  • spinal cord
  • stem cells
  • bone marrow