A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4 + and CD8 + T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection.
Latifa ZayouSwayam PrakashNisha Rajeswari DhanushkodiAfshana QuadiriIzabela Coimbra IbraimMahmoud SingerAmirah SalemAmin Mohammed ShaikBerfin SuzerAmruth ChilukuriJennifer TranPauline Chau NguyenMiyo SunKathy K Hormi-CarverAhmed BelmoudenHawa VahedDaniel GilJeffrey B UlmerLbachir BenMohamedPublished in: Journal of virology (2023)
memory T cells in the lungs of SARS-CoV-2-infected triple transgenic HLA-DR*0101/HLA-A*0201/hACE2 mouse model, thereby resulting in low viral titer and reduced COVID-19-like symptoms.