Diagnosis, management and follow-up of follicular lymphoma: a consensus practice statement from the Australasian Lymphoma Alliance.
Josuha W D TobinGregory HapgoodAnna JohnstonChan Y CheahSze T LeeJudith TrotmanShafqat InamBelinda A CampbellDebbie NorrisMichael MacManusMark HertzbergEliza A HawkesPublished in: Internal medicine journal (2024)
Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma subtype, accounting for 15-20% of all lymphoma diagnoses. Although typically slow-growing and responsive to frontline therapies, advanced-stage FL remains incurable with current treatments and typically follows a chronic relapsing/remitting course with increasingly shorter responses to subsequent lines of therapy. Outcomes are highly variable; some patients experience prolonged first remissions that may approximate a 'functional cure'. By contrast, a significant minority of patients experience disease progression shortly after frontline treatment resulting in high rates of lymphoma-related mortality. Reflecting on the heterogeneous natural history of FL, clinical practice varies widely, particularly in controversial areas, including appropriate disease staging, selection of management strategies and duration of clinical follow-up. This position statement presents an evidence-based synthesis of the literature for application in Australasian practice.
Keyphrases
- end stage renal disease
- multiple sclerosis
- clinical practice
- newly diagnosed
- ejection fraction
- healthcare
- diffuse large b cell lymphoma
- primary care
- peritoneal dialysis
- systematic review
- type diabetes
- lymph node
- magnetic resonance
- patient reported outcomes
- magnetic resonance imaging
- computed tomography
- mesenchymal stem cells
- cardiovascular disease
- cardiovascular events
- coronary artery disease
- cancer therapy
- rheumatoid arthritis
- risk factors
- drug delivery
- combination therapy
- replacement therapy
- smoking cessation