Urinary volatile organic compounds and faecal microbiome profiles in colorectal cancer.
Michael McFarlaneA MillardH HallR SavageC ConstantinidouRamesh Pulendran ArasaradnamC NwokoloPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2019)
Although CRC patients' urinary VOC profiles cannot be differentiated from those of spouses or relatives they can be differentiated from a larger non-cancer control group. Comparison of the groups' microbiomes confirmed differences in bacterial species abundance. The current FAIMS-based assay can detect a unique, but modest, signal in CRC patients' urinary VOCs, which remains unaltered after treatment.