Hypoxic colorectal cancer-derived extracellular vesicles deliver microRNA-361-3p to facilitate cell proliferation by targeting TRAF3 via the noncanonical NF-κB pathways.

Jie LiPeng YangFangyu ChenYuqian TanChangzhi HuangHengyang ShenChaofan PengYifei FengYueming Sun

Published in: Clinical and translational medicine (2022)

Altogether, the abnormality of exosomal miR-361-3p derived from hypoxia acts vital roles in the regulation of CRC growth and apoptosis and can be an emerging prognostic biomarker and a therapeutic target for CRC patients.

Keyphrases

cell proliferation
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
signaling pathway
pi k akt
peritoneal dialysis
prognostic factors
cell death
endoplasmic reticulum stress
cell cycle arrest
cell cycle
lps induced
patient reported outcomes
nuclear factor
toll like receptor