Type 2 diabetes mellitus facilitates status epilepticus in adult rats: Seizure severity, neurodegeneration, and oxidative stress.
Karen Paola Ramos-RieraLuis Beltrán-ParrazalConsuelo Morgado-ValleFrancisca Pérez-SeverianoPablo Eliasib Martínez-GoparMaría-Leonor López-MerazPublished in: Epilepsia open (2024)
Our research performed in animal models suggests that type 2 diabetes mellitus (DM2) may be a risk factor for causing higher seizure severity and seizure-induced neuron cell death. However, even when long-term seizures promote an imbalance between brain pro-oxidants and antioxidants, DM2 does not exacerbate that disproportion.
Keyphrases
- glycemic control
- temporal lobe epilepsy
- cell death
- oxidative stress
- diabetic rats
- type diabetes
- high glucose
- dna damage
- cardiovascular risk factors
- resting state
- white matter
- weight loss
- insulin resistance
- ischemia reperfusion injury
- signaling pathway
- adipose tissue
- brain injury
- cell proliferation
- young adults
- subarachnoid hemorrhage
- childhood cancer
- heat shock