The proprotein convertase FURIN is a novel aneurysm predisposition gene impairing TGF-β signaling.
Zongsheng HeArne S IJpmaDianne VreekenDaphne HeijsmanKaren RosierHence J M VerhagenJorg de BruinHennie T BrüggenwirthJolien W Roos-HesselinkJos A BekkersDanny HuylebroeckHeleen van BeusekomJohn W M CreemersDanielle Majoor-KrakauerPublished in: Cardiovascular research (2024)
FURIN is a novel, frequent genetic predisposition for abdominal-, thoracic-, and multiple aortic or middle sized artery aneurysms in older patients, by affecting intracellular TGF-β signaling, depending on individual genetic backgrounds.