CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation.

Juan WangHaoye ZhangLimin ChenKangkang FuYu YanZhen-Guo Liu

Published in: Journal of gastroenterology (2024)

CircDCBLD2 overexpression increased PARK7 ubiquitination degradation by upregulating STUB1 through its interaction with HuR, inhibiting HSC activation and promoting HSC ferroptosis, ultimately enhancing liver fibrosis.

Keyphrases

liver fibrosis
cell death
cell proliferation
signaling pathway
transcription factor
binding protein
mouse model