PARK7/DJ-1 inhibition decreases invasion and proliferation of uveal melanoma cells.

Nerea Lago-BaameiroMaria Santiago-VarelaTamara CaminoPaula Silva-RodríguezManuel BandeMaria Jose Blanco-TeijeiroMaria PardoAntonio Piñeiro

Published in: Tumori (2021)

DJ-1 appears to play a key role on the PTEN/Akt pathway in UM. DJ-1 inhibition appears to have a negative effect on proliferation and invasion of UM cells. This suggests DJ-1 as a potential therapeutic target in UM.

Keyphrases

signaling pathway
induced apoptosis
cell proliferation
cell cycle arrest
cell migration
endoplasmic reticulum stress
climate change