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Heteroaryl derivatives of suvorexant as OX1R selective PET ligand candidates: Cu-mediated 18 F-fluorination of boroxines, in vitro and initial in vivo evaluation.

Kim-Viktoria BolikJan HellmannSimone MaschauerEduard NeuJürgen EinsiedelPatrick RissNora VoggJörg KönigMartin F FrommHarald HübnerPeter GmeinerOlaf Prante
Published in: EJNMMI research (2024)
F]1f provide a solid basis for further development of suitable OXR PET ligands for brain imaging.
Keyphrases
  • pet ct
  • positron emission tomography
  • computed tomography
  • pet imaging
  • high resolution
  • resting state
  • white matter
  • functional connectivity
  • structure activity relationship
  • low density lipoprotein