SS18-SSX-Dependent YAP/TAZ Signaling in Synovial Sarcoma.

Ilka IsfortMagdalene CyraSandra ElgesSareetha KailayangiriBianca Altvater Claudia RossigKonrad SteinestelInga GrünewaldSebastian HussEva EßelingJan-Henrik MikeschSusanne HafnerThomas SimmetAgnieszka WozniakPatrick SchöffskiOlle LarssonEva WardelmannMarcel TrautmannWolfgang Hartmann

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Our preclinical study identifies an elementary role of SS18-SSX-driven YAP/TAZ signals, highlights the complex network of oncogenic signaling pathways in synovial sarcoma pathogenesis, and provides evidence for innovative therapeutic approaches.

Keyphrases

signaling pathway
genome wide
transcription factor
cell therapy
gene expression
cell proliferation
bone marrow