White matter hyperintensities mediate the association of nocturnal blood pressure with cognition.
Anthony G ChesebroJesus D MelgarejoReinier LeendertzKay C IgwePatrick J LaoKrystal K LaingBatool RizviMariana BudgeIrene B MeierGustavo CalmonJoseph H LeeGladys E MaestreAdam M BrickmanPublished in: Neurology (2020)
Reverse dipping in the presence of hypertension is associated with small vessel cerebrovascular disease, which, in turn, mediates memory functioning. These results point toward reverse dipping as a marker of poor nocturnal blood pressure control, particularly among hypertensive individuals, with potentially pernicious effects on cerebrovascular health and associated cognitive function.
Keyphrases
- blood pressure
- white matter
- hypertensive patients
- heart rate
- healthcare
- public health
- multiple sclerosis
- mental health
- working memory
- blood glucose
- sensitive detection
- mild cognitive impairment
- living cells
- type diabetes
- health promotion
- climate change
- physical activity
- weight loss
- quantum dots
- insulin resistance
- sleep apnea