Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19.
Shashank AgarwalJenna ConwayV NguyenSiddhant DograPenina KriegerDavid ZagzagAriane LewisKara R MelmedSteven L GalettaRajan JainPublished in: AJNR. American journal of neuroradiology (2020)
Critically ill patients with COVID-19 can develop acute disseminated leukoencephalopathy that evolves into cystic degeneration of white matter lesions with brain atrophy during a short period, which we dubbed virus-associated necrotizing disseminated acute leukoencephalopathy. This may be the result of COVID-19-related endothelial injury, cytokine storm, or thrombotic microangiopathy.