Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19.

Shashank Agarwal Jenna Conway V Nguyen Siddhant Dogra Penina Krieger David Zagzag Ariane Lewis Kara R Melmed Steven L Galetta Rajan Jain

Published in: AJNR. American journal of neuroradiology (2020)

Critically ill patients with COVID-19 can develop acute disseminated leukoencephalopathy that evolves into cystic degeneration of white matter lesions with brain atrophy during a short period, which we dubbed virus-associated necrotizing disseminated acute leukoencephalopathy. This may be the result of COVID-19-related endothelial injury, cytokine storm, or thrombotic microangiopathy.

Keyphrases

liver failure
white matter
coronavirus disease
respiratory failure
sars cov
drug induced
high resolution
hepatitis b virus
endothelial cells
intensive care unit
resting state
respiratory syndrome coronavirus
functional connectivity
photodynamic therapy
brain injury
cerebral ischemia