Sarcosine influences apoptosis and growth of prostate cells via cell-type specific regulation of distinct sets of genes.

Miguel A Merlos RodrigoVladislav StrmiskaEva HorackovaHana BuchtelovaPetr MichalekMarie StiborovaTomas EckschlagerVojtech AdamZbynek Heger

Published in: The Prostate (2017)

Our comparative study brings evidence that sarcosine affects not only metastatic PCa cells, but also their malignant and non-malignant counterparts and induces very similar changes in cells behavior, but via distinct cell-type specific targets.

Keyphrases

cell cycle arrest
induced apoptosis
endoplasmic reticulum stress
cell death
prostate cancer
squamous cell carcinoma
small cell lung cancer
oxidative stress
pi k akt
genome wide
gene expression
transcription factor
dna methylation
benign prostatic hyperplasia