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Prognostic significance of combined pretreatment lymphocyte counts and body mass index in patients with head and neck cancer treated with radiation therapy.

Yao-Yu WuKai-Ping ChangChien-Yu LinPing-Ching PaiHung-Ming WangCheng-Lung HsuChun-Ta LiaoTzu-Chen YenTuan-Jen FangShiang-Fu HuangChung-Jan KangKu-Hao FangWan-Ni LinYu-Chien WangLi-Jen HsinNgan-Ming Tsang
Published in: Cancer medicine (2018)
We aimed to investigate the prognostic significance of combined pretreatment lymphocyte counts (LCs) and body mass index (BMI) in patients with head and neck cancer (HNC) treated with radiation therapy (RT). Nine hundred and twelve patients with HNC who were treated with RT were retrospectively reviewed. Survival was analyzed by stratifying the patients according to pretreatment LCs and BMI. Patients with low pretreatment LCs and BMI were characterized by a more advanced T stage, fewer nasopharyngeal subsites, less smoking and drinking, and fewer comorbidities. Patients with low pretreatment LCs and BMI had a significantly poorer overall and distant metastasis-free survival than those with high pretreatment LCs and BMI. No significant differences were observed in terms of local or regional recurrence-free survival. Combined pretreatment LCs and BMI may be more effective at predicting overall and distant metastasis-free survival in patients with HNC treated with RT.
Keyphrases
  • free survival
  • body mass index
  • weight gain
  • radiation therapy
  • newly diagnosed
  • end stage renal disease
  • lymph node
  • ejection fraction
  • chronic kidney disease
  • patient reported outcomes
  • prognostic factors