The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis.
Shivani SinghSimon BoydWilliam H K SchillingJames A WatsonMavuto MukakaNicholas J WhitePublished in: The Journal of antimicrobial chemotherapy (2024)
Methods of determining viral clearance in COVID-19 studies and the relationship to clinical outcomes vary greatly. As prohibitively large sample sizes are now required to show clinical treatment benefit in antiviral therapeutic assessments, viral clearance is a reasonable surrogate endpoint.