Effect of high-dose intravenous methylprednisolone pulse (IVMP) therapy in the survival of patients with anti-melanoma differentiation-associated gene 5-related rapidly progressive interstitial lung disease: a retrospective analysis.

Li FanYan LiWenting LyuQingqing XuYujuan GaoXiaohua QiuHourong CaiJinghong Dai

Published in: Clinical rheumatology (2024)

Our study showed that the survival benefits and adverse events were comparable between IVMP-treated and untreated MDA5-RPILD patients. Future prospective trials are needed to investigate the optimal treatment regimen in MDA5-RPILD. Key Points • This observational study found that IVMP therapy may be not associated with an improved outcome in patients with MDA5-RPILD. • Treatment-related infections are common; however, the incidence of treatment-related infections had no difference between IVMP and non-IVMP group.

Keyphrases

high dose
interstitial lung disease
systemic sclerosis
breast cancer cells
newly diagnosed
low dose
end stage renal disease
gene expression
rheumatoid arthritis
cell death
idiopathic pulmonary fibrosis
cell proliferation
stem cell transplantation
replacement therapy
cell cycle arrest
current status