Proteomic analyses reveal plasma EFEMP1 and CXCL12 as biomarkers and determinants of neurodegeneration.
Michael R DugganZhijian YangYuhan CuiHeather E DarkJunhao WenGuray ErusTimothy J HohmanJingsha ChenAlexandria LewisAbhay MoghekarJosef CoreshSusan M ResnickChristos DavatzikosKeenan A WalkerPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Plasma proteomic signatures are associated with unique patterns of brain atrophy. Brain atrophy-related proteins predict clinically relevant outcomes across cohorts. Genetic variation underlying plasma EFEMP1 and CXCL12 influences brain structure. EFEMP1 and CXCL12 may be important molecular drivers of neurodegeneration.