Tandem high-dose chemotherapy with topotecan-thiotepa-carboplatin and melphalan-etoposide-carboplatin regimens for pediatric high-risk brain tumors.

Jung Yoon ChoiHyoung Jin KangKyung Taek HongChe Ry HongYun Jeong LeeJune Dong ParkJi Hoon PhiSeung-Ki KimKyu-Chang WangIl Han KimSung-Hye ParkYoung Hun ChoiJung-Eun CheonKyung Duk ParkHee Young Shin

Published in: International journal of clinical oncology (2019)

Although tandem HDC/auto-SCT with TTC/MEC regimens showed promising survival rates, treatment modifications are warranted to reduce toxicities. The survival rates with relapsed brain tumors were unsatisfactory despite HDC/auto-SCT, and further study is needed.

Keyphrases

high dose
phase ii study
low dose
stem cell transplantation
acute lymphoblastic leukemia
free survival
acute myeloid leukemia
diffuse large b cell lymphoma
multiple myeloma
locally advanced
hodgkin lymphoma
squamous cell carcinoma
replacement therapy
childhood cancer