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The EpiDiverse Plant Epigenome-Wide Association Studies (EWAS) Pipeline.

Sultan Nilay CanAdam NunnDario GalantiDavid LangenbergerClaude BeckerKatharina VolmerKatrin HeerLars OpgenoorthNoe Fernandez PozoStefan A Rensing
Published in: Epigenomes (2021)
Bisulfite sequencing is a widely used technique for determining DNA methylation and its relationship with epigenetics, genetics, and environmental parameters. Various techniques were implemented for epigenome-wide association studies (EWAS) to reveal meaningful associations; however, there are only very few plant studies available to date. Here, we developed the EpiDiverse EWAS pipeline and tested it using two plant datasets, from P. abies (Norway spruce) and Q. lobata (valley oak). Hence, we present an EWAS implementation tested for non-model plant species and describe its use.
Keyphrases
  • dna methylation
  • genome wide
  • case control
  • gene expression
  • single cell
  • primary care
  • healthcare
  • rna seq
  • risk assessment