A study of the mechanism of lncRNA-CR594175 in regulating proliferation and invasion of hepatocellular carcinoma cells in vivo and in vitro.

Quan LiuXuxu YuMinjie YangXiangke LiXuejia ZhaiYujin LianZhong ChenQingxia FanLijie SongWencai Li

Published in: Infectious agents and cancer (2020)

Our present study demonstrated for the first time that lncRNA-CR594175 silencing suppressed proliferation and invasion of HCC cells in vivo and in vitro by restoring the negative regulation of hsa-miR-142-3p on CTNNB1, laying a solid theoretical base for using lncRNA-CR594175 as genetic target therapy for HCC and offering a reasonable explanation for inactivation of miRNA in different tumors or in the tumor at different stages.

Keyphrases

long non coding rna
long noncoding rna
induced apoptosis
cell cycle arrest
genome wide
heat stress
gene expression
cell death
endoplasmic reticulum stress
signaling pathway