Children with extended oligoarticular and polyarticular juvenile idiopathic arthritis have alterations in B and T follicular cell subsets in peripheral blood and a cytokine profile sustaining B cell activation.
Catarina ToméFilipa Oliveira-RamosRaquel Campanilho-MarquesAna Filipa MourãoSandra SousaCláudia MarquesAna T MeloRui L TeixeiraAna P MartinsSofia MoedaPatrícia Costa-ReisRita P TorresMatilde BandeiraHelena FonsecaMiroslava GonçalvesMaria Jose SantosLuís GraçaJoão Eurico FonsecaRita A MouraPublished in: RMD open (2023)
Our results suggest a potential role and/or activation profile of B and Th17-like Tfh cells in the pathogenesis of extended oligo JIA and poly JIA, but not persistent oligo JIA.