Pharmacological HIF-PHD inhibition reduces renovascular resistance and increases glomerular filtration by stimulating nitric oxide generation.
Mikhail BurmakinAngelica FaschingHanako KobayashiAndres A UrrutiaAnastasios DamdimopoulosFredrik PalmVolker H HaasePublished in: Acta physiologica (Oxford, England) (2021)
Our data provide mechanistic insights into dose-dependent effects of short-term pharmacological HIF activation on renal haemodynamics, glomerular filtration and O2 metabolism and identify NO as a major mediator of these effects.