Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint.

Kei InomataKunikazu TsujiHiroaki OnumaTakashi HoshinoMio UdoMasako AkiyamaYusuke NakagawaHiroki KatagiriKazumasa MiyatakeIchiro SekiyaTakeshi MunetaHideyuki Koga

Published in: BMC musculoskeletal disorders (2019)

Our data indicated that acute joint pain occurs along with the onset of acute inflammatory process. Irreversible structural changes in the IFP, such as extensive fibrosis, are observed prior to persistent pain development. Thus, we consider that this process may play important roles in persistent pain development.

Keyphrases

chronic pain
pain management
neuropathic pain
oxidative stress
liver failure
drug induced
intensive care unit
spinal cord
electronic health record
diabetic rats
aortic dissection
endothelial cells
artificial intelligence
big data
extracorporeal membrane oxygenation