Resting Whole Body Energy Metabolism in Class 3 Obesity; from Preserved Insulin Sensitivity to Overt Type 2 Diabetes.
Giuseppina ManzoniAlice OltoliniSilvia PerraEmanuele MuracaStefano CiardulloMattia PizziGiovanna CastoldiGuido LattuadaPietro PizziGianluca PerseghinPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
Class 3 obese patients with normal insulin sensitivity are characterized by reduced fasting REE in comparison to insulin-resistant obese patients and obese patients with short duration of diabetes supporting the hypothesis that down-regulation of nutrients' oxidative disposal may represent an adaptation of energy metabolism in obese individuals with preserved insulin sensitivity.