Development and characterisation of NKp44-based chimeric antigen receptors that confer T cells with NK cell-like specificity.

Yasushi KasaharaChansu ShinNobuhiro KuboKeichiro MiharaHaruko IwabuchiTakayuki TakachiMasaru ImamuraAkihiko SaitohChihaya Imai

Published in: Clinical & translational immunology (2020)

NKp44-based CAR endows T cells with NK cell-like anti-tumor specificity. The CAR gene created in this study will be useful for the development of novel gene-modified T-cell immunotherapy.

Keyphrases

nk cells
genome wide
copy number
cell therapy
genome wide identification
stem cells
gene expression
structural basis