Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases.
Julie SarrandMuhammad Shahnawaz SoyfooPublished in: International journal of molecular sciences (2023)
Epithelial-mesenchymal transition (EMT) is a complex reversible biological process characterized by the loss of epithelial features and the acquisition of mesenchymal features. EMT was initially described in developmental processes and was further associated with pathological conditions including metastatic cascade arising in neoplastic progression and organ fibrosis. Fibrosis is delineated by an excessive number of myofibroblasts, resulting in exuberant production of extracellular matrix (ECM) proteins, thereby compromising organ function and ultimately leading to its failure. It is now well acknowledged that a significant number of myofibroblasts result from the conversion of epithelial cells via EMT. Over the past two decades, evidence has accrued linking fibrosis to many chronic autoimmune and inflammatory diseases, including systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and inflammatory bowel diseases (IBD). In addition, chronic inflammatory states observed in most autoimmune and inflammatory diseases can act as a potent trigger of EMT, leading to the development of a pathological fibrotic state. In the present review, we aim to describe the current state of knowledge regarding the contribution of EMT to the pathophysiological processes of various rheumatic conditions.
Keyphrases
- epithelial mesenchymal transition
- systemic sclerosis
- rheumatoid arthritis
- systemic lupus erythematosus
- disease activity
- extracellular matrix
- transforming growth factor
- interstitial lung disease
- signaling pathway
- oxidative stress
- multiple sclerosis
- healthcare
- squamous cell carcinoma
- stem cells
- small cell lung cancer
- bone marrow
- ankylosing spondylitis
- physical activity
- weight gain
- body mass index