Colorectal Cancer Stem Cells Fuse with Monocytes to Form Tumour Hybrid Cells with the Ability to Migrate and Evade the Immune System.
Karla Montalbán-HernándezRamón Cantero-CidJosé Carlos Casalvilla-DueñasJosé Avendaño-OrtizElvira MarínRoberto Lozano-RodríguezVerónica Terrón-ArcosMarina Vicario-BravoCristóbal MarcanoJorge Saavedra-AmbrosyJulia Prado-MonteroJaime ValentínRebeca Pérez de DiegoLaura CórdobaElisa PulidoCarlos Del Fresno SánchezMarta DueñasEduardo López-CollazoPublished in: Cancers (2022)
Our results indicate the generation of a hybrid entity after the in vitro co-culture between CRC stem cells and human monocytes. Moreover, THC numbers present in patients are related to both prognosis and the later spread of metastases in CRC patients.