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Pulmonary Hypertension Induces Serotonin Hyperreactivity and Metabolic Reprogramming in Coronary Arteries via NOX1/4-TRPM2 Signaling Pathway.

Yan-Zhen HuangJi-Chun WuGui-Feng LuHui-Bin LiSu-Mei LaiYi-Chen LinLong-Xin GuiJames S K ShamMo-Jun LinDa-Cen Lin
Published in: Hypertension (Dallas, Tex. : 1979) (2024)
PH triggers an increase in 5-hydroxytryptamine reactivity in the right CA and provokes metabolic reprogramming and mitochondrial disruption in CA smooth muscle cells via NOX1/4-TRPM2 activation. This signaling pathway may play an important role in CA remodeling and CA disease in PH.
Keyphrases
  • signaling pathway
  • pulmonary hypertension
  • protein kinase
  • pi k akt
  • epithelial mesenchymal transition
  • coronary artery disease
  • coronary artery
  • induced apoptosis
  • cell proliferation
  • left ventricular