PROPHETIC EU: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit in European and United States Cohorts.
Stephen P BerginSara B CalvertJohn FarleyJie-Lena SunKaren ChiswellWillem DieperinkJan KluytmansJuan Carlos Lopez-DelgadoRafael Leon-LopezMarcus J ZervosMarin H KollefMatthew SimsBadih A KabchiDaniel RubinJonas SantiagoMukil NatarajanPamela TenaertsVance G FowlerThomas L HollandMarc J BontenSebastiaan J HullegiePublished in: Open forum infectious diseases (2022)
Clinical criteria prospectively identified high-risk patients with high rates of pneumonia in the European cohort. Despite higher rates of established risk factors and incident pneumonia, European patients were significantly less likely to receive antibiotics for possible pneumonia than US patients. Different treatment practices may contribute to lower rates of antibacterial trial enrollment in the United States.