NUPR1 packaged in extracellular vesicles promotes murine triple-negative breast cancer in a type 1 interferon-independent manner.

Angelica OrtizAikaterini StavrouShan LiuDanqi ChenSteven S ShenChunyuan Jin

Published in: Extracellular vesicles and circulating nucleic acids (2024)

In conclusion, our study suggests that TNBC is driven by aberrant packaging of NUPR1 into TEVs which were transferred into recipient cells to activate pro-metastatic transcription driven by NUPR1.

Keyphrases

induced apoptosis
squamous cell carcinoma
small cell lung cancer
cell cycle arrest
dendritic cells
transcription factor
anti inflammatory
oxidative stress