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Single-cell profile of tumor and immune cells in primary breast cancer, sentinel lymph node, and metastatic lymph node.

Ning LiaoCheukfai LiLi CaoYanhua ChenChongyang RenXiaoqing ChenHsiaopei MokLingzhu WenKai LiYulei WangYuchen ZhangYingzi LiJiaoyi LvFangrong CaoYuting LuoHongrui LiJiayan WuCharles M BalchArmando E Giuliano
Published in: Breast cancer (Tokyo, Japan) (2022)
Single-cell sequencing analysis suggested that the sentinel lymph node was the initial meeting site of tumor infiltration and immune response, where partial T lymphocytes perform anti-tumor activity, while other T cells exhibit an exhausted state. We proposed a molecular explanation to the well-established clinical principle that the 5-year and 10-year survival outcomes were noninferior between SLND and ALND.
Keyphrases
  • sentinel lymph node
  • lymph node
  • single cell
  • neoadjuvant chemotherapy
  • rna seq
  • early stage
  • immune response
  • high throughput
  • small cell lung cancer
  • squamous cell carcinoma
  • dendritic cells
  • single molecule