MHC class I molecules co-stimulate NK1.1 signaling and enhance Ca2+ flux in murine NK cells.
Sridharan GanesanPetter HöglundPublished in: European journal of immunology (2021)
Simultaneous triggering of NK1.1 and MHC class I on NK cells gives a higher Ca2+ flux response compared to triggering the NK1.1 receptor alone. The data suggest a novel costimulatory role for MHC class I molecules on NK cell responses.