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MHC class I molecules co-stimulate NK1.1 signaling and enhance Ca2+ flux in murine NK cells.

Sridharan GanesanPetter Höglund
Published in: European journal of immunology (2021)
Simultaneous triggering of NK1.1 and MHC class I on NK cells gives a higher Ca2+ flux response compared to triggering the NK1.1 receptor alone. The data suggest a novel costimulatory role for MHC class I molecules on NK cell responses.
Keyphrases
  • nk cells
  • electronic health record
  • protein kinase