Green Synthesis of Gold Nanoparticles Using Polianthes tuberosa L. Floral Extract.
Mousa A AlghuthaymiChandrasekaran RajkuberanThiyagaraj SanthiyaOndrej KrejcarTeodorico C RamalhoRajiv PeriakaruppanSeetharaman PrabukumarPublished in: Plants (Basel, Switzerland) (2021)
The developments of green-based metallic nanoparticles (gold) are gaining tremendous interest, having potential applications in health care and diagnosis. Therefore, in the present study, Polianthes tuberosa flower filtered extract was used as a reducing and stabilizing agent to synthesize gold nanoparticles (PtubAuNPs). The PtubAuNPs were extensively characterized by UV-visible spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, and X-ray diffraction. The antibacterial activity of PtubAuNPs was determined by the agar well diffusion method; the PtubAuNPs performed extreme antagonistic activity against the tested pathogens. Furthermore, the cytotoxicity of the PtubAuNPs was evaluated in MCF 7 cells by MTT assay. The PtubAuNPs induced toxicity in MCF 7 cells with the least concentration of 100 µg/mL in a dose-dependent method by inducing apoptosis. Overall, the study manifested that PtubAuNPs are a potent nanomaterial that can be employed as an antimicrobial and anticancer agent.
Keyphrases
- gold nanoparticles
- cell cycle arrest
- induced apoptosis
- oxidative stress
- electron microscopy
- healthcare
- endoplasmic reticulum stress
- high resolution
- breast cancer cells
- staphylococcus aureus
- diabetic rats
- anti inflammatory
- high throughput
- magnetic resonance imaging
- computed tomography
- magnetic resonance
- multidrug resistant
- risk assessment
- mass spectrometry
- climate change
- signaling pathway
- cell proliferation
- endothelial cells
- single cell