Genetically instrumented LDL-cholesterol lowering and multiple disease outcomes: a Mendelian randomisation phenome-wide association study in the UK Biobank.

Kitty Pham Anwar Mulugeta Amanda L Lumsden Elina Hyppӧnen

Published in: British journal of clinical pharmacology (2023)

We found genetic evidence to support both positive and negative effects of LDL-C lowering through all four LDL-C-lowering pathways. Future studies should further explore the effects of LDL-C lowering on lung function and changes in brain volume.

Keyphrases

low density lipoprotein
lung function
chronic obstructive pulmonary disease
cystic fibrosis
air pollution
genome wide
current status
copy number
adipose tissue
insulin resistance
dna methylation