Intestinal microbiota regulates anti-tumor effect of disulfiram combined with Cu2+ in a mice model.
Hong HuLanyue CuiJiachen LuKehong WeiJing WeiShaobo LiChangwei ZouTing-Tao ChenPublished in: Cancer medicine (2020)
The disturbed intestinal microbiota (increased abundance of opportunistic pathogens Campylobacterales, Helicobacteraceae, and Coriobacteriaceae) and the over-activated TLR4/NF-κB signaling pathway in tumor tissues deteriorated the cancer development, and the using of antibiotics is benefit to enhance the therapeutic effect of DSF on tumors via inhibiting the growth of opportunistic pathogenic bacteria.
Keyphrases
- signaling pathway
- pi k akt
- papillary thyroid
- epithelial mesenchymal transition
- induced apoptosis
- toll like receptor
- inflammatory response
- gene expression
- squamous cell
- immune response
- gram negative
- nuclear factor
- high fat diet induced
- antimicrobial resistance
- lps induced
- squamous cell carcinoma
- antibiotic resistance genes
- microbial community
- metabolic syndrome
- wastewater treatment
- wild type
- aqueous solution