A ratiometric fluorescent DNA nanoprobe for cerebral adenosine triphosphate assay.
Zhichao LiuPeicong WuYaoyao YinYang TianPublished in: Chemical communications (Cambridge, England) (2019)
A silver nanocluster-based ratiometric fluorescent nanosensor was developed for the determination of ATP in the cerebrospinal fluid of a mouse brain. Using this useful tool with good stability and high selectivity as well as a wide linear detection range, it was found that the ATP concentration in a mouse brain with Alzheimer's disease was 2300-fold higher than that in a normal one.
Keyphrases
- living cells
- fluorescent probe
- single molecule
- cerebrospinal fluid
- quantum dots
- gold nanoparticles
- subarachnoid hemorrhage
- circulating tumor
- label free
- high throughput
- cell free
- loop mediated isothermal amplification
- sensitive detection
- solid phase extraction
- real time pcr
- molecularly imprinted
- silver nanoparticles
- brain injury
- single cell
- tandem mass spectrometry
- blood brain barrier