VEGF-C overexpression in kidney progenitor cells is a model of renal lymphangiectasia.

Michael D Donnan Dilip K DebValentin DavidSusan E Quaggin

Published in: bioRxiv : the preprint server for biology (2023)

mice. There were no changes in peritubular blood capillary density despite these endothelial cells also expressing VEGFR-3. The model resulted in a severe cystic kidney phenotype that resembled a human condition termed renal lymphangiectasia. This study defines the vascular consequences of augmenting VEGF-C signaling during kidney development and provides new insight into a mimicker of human cystic kidney disease.

Keyphrases

endothelial cells
vascular endothelial growth factor
high glucose
early onset
transcription factor
induced pluripotent stem cells
metabolic syndrome
high fat diet induced
type diabetes
drug induced