Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis.

Susan MacLauchlanMaria A ZuriagaJosé J FusterCarla M CudaJennifer JonasonFernanda BehzadiJennifer Parker DuffenG Kenneth HainesTamar AprahamianHarris PerlmanKenneth Walsh

Published in: Arthritis research & therapy (2017)

These data suggest that Wnt5a modulates the development of arthritis by promoting inflammation and osteoclast fusion, and provide the first mouse genetic evidence of a role for endogenous Wnt5a in autoimmune disease.

Keyphrases

rheumatoid arthritis
cell proliferation
stem cells
genome wide
oxidative stress
multiple sclerosis
disease activity
copy number
electronic health record
big data
gene expression
ankylosing spondylitis
systemic lupus erythematosus
replacement therapy