DNA methylation of blood cells is associated with prevalent type 2 diabetes in a meta-analysis of four European cohorts.

Diana L Juvinao-QuinteroRiccardo E MarioniCarolina Ochoa-RosalesTom C RussIan J DearyJoyce B J van MeursTrudy VoortmanMarie-France HivertGemma C SharpCaroline L ReltonHannah R Elliott

Published in: Clinical epigenetics (2021)

This study identifies novel loci associated with T2D in Europeans. We also demonstrate associations of the same loci with other traits. Future studies should investigate if our findings are generalizable in non-European populations, and potential roles of these epigenetic markers in T2D etiology or in determining long term consequences of T2D.

Keyphrases

genome wide
dna methylation
type diabetes
gene expression
induced apoptosis
copy number
cell cycle arrest
genome wide association study
cardiovascular disease
insulin resistance
oxidative stress
skeletal muscle
cell death
signaling pathway
climate change
human health