Influence of pre-analytical sample preparation on drug concentration measurements in peritoneal tissue: an ex-vivo study.
Arianna CastagnaIaroslav SautkinFrank-Jürgen WeinreichHannah Heejung LeeAlfred KönigsrainerMarc André ReymondGiorgi NadiradzePublished in: Pleura and peritoneum (2021)
Measurements of drug concentration in peritoneal tissue can be influenced by the biopsy's surface/depth ratio and after drying the biopsy's surface. This influence can reach a factor three, depending on the drug tested. The biopsy technique and the pre-analytical sample preparation should be standardized to ensure reliable pharmacological measurements in peritoneal tissue.