Establishment of patient-derived xenograft model of peritoneal mucinous carcinomatosis with signet ring cells and in vivo study on the efficacy and toxicity of intraperitoneal injection of 5-fluorouracil.

Yu-Lin LinJue ZhangFeng-Cai YanXi JiangRu MaZhi-Ran YangHong-Bin XuZheng PengQian ChenYan Li

Published in: Cancer medicine (2019)

PDX model of PMCA-S was established successfully, and i.p. 5-FU could inhibit tumor proliferation and progression, with decreased Ki67 positive rate and ePCI score. Hepatotoxicity was the main side effect.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
low grade
neoadjuvant chemotherapy
cell proliferation
lymph node
cell death
endoplasmic reticulum stress
high grade
pi k akt
rectal cancer