Vancomycin Dosing and Its Association With Acute Kidney Injury in Pediatric Cardiac Intensive Care Patients Under 3 Months of Age.
Liat Ashkenazi-HoffnungOfer SchillerMor KrubinerOvadia DaganOrly HaskinOrit Manor-ShulmanYael FeinsteinTzippy ShochatEran ShostakHavatzelet Yarden-BilavskyPublished in: The Pediatric infectious disease journal (2024)
Our results support a lower starting vancomycin dose of ~30 mg/kg/day followed by an early personalized therapeutic approach, to achieve therapeutic trough concentrations of 10-20 mg/L in cardiac postoperative term infants. Supratherapeutic concentrations are associated with an increased risk for AKI, which is prevalent in this population and associated with adverse outcomes.
Keyphrases
- end stage renal disease
- left ventricular
- ejection fraction
- newly diagnosed
- chronic kidney disease
- methicillin resistant staphylococcus aureus
- acute kidney injury
- prognostic factors
- preterm infants
- patients undergoing
- peritoneal dialysis
- heart failure
- patient reported outcomes
- staphylococcus aureus
- atrial fibrillation
- young adults