Antibody binding and ACE2 binding inhibition is significantly reduced for both the BA1 and BA2 omicron variants.
Daniel JunkerMatthias BeckerTeresa R WagnerPhilipp D KaiserSandra MaierTanja M GrimmJohanna GriesbaumPatrick MarsallJens GruberBjoern TraenkleConstanze HeinzelYudi T PinillaJana HeldRolf FendelAndrea KreidenweissAnnika NeldeYacine MaringerSarah SchroederJuliane S WalzKarina AlthausGunalp UzunMarco MikusTamam BakchoulKatja Schenke-LaylandStefanie BunkHelene HaeberleSiri GöpelMichael BitzerHanna RenkJonathan RemppisCorinna EngelAxel R FranzManuela HarriesBarbora KesselBerit LangeMonika StrengertGerard KrauseAnne ZeckUlrich RothbauerAlex DulovicNicole Schneiderhan-MarraPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
omicron BA1 and BA2 can still efficiently bind to ACE2, while vaccine/infection-derived antibodies can bind omicron. The extent of the mutations within both variants prevent a strong inhibitory binding response. As a result, both omicron variants are able to evade control by pre-existing antibodies.